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In this study, glutamine flux was directed toward the generation of R-2-HG in IDH1/2 mutant cells, and the kinetics of R-2-HG formation were proportionally of the same order of magnitude as those of glutamate or -KG formation via glutaminolysis

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Because of this, the manufacturer did not take the concept further. When SGLT-2 inhibitors like Invokana, Farxiga, and Jardiance emerged in 2013 and 2014, researchers began testing these medications in type 1 diabetes in a series of trials

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