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Ethics statement The studies involving humans were approved by Slovenian National Medical Ethics Committee (approval number 0120-258/2019/12)

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Trial 7, which provided data from both subcutaneous and intravenous administration, allowed the absolute bioavailability for subcutaneous administration of semaglutide to be estimated

No published Phase I trial establishing tolerability, human pharmacokinetics or dose escalation was identified

36 Additionally, non-biological factors such as sex-specific differences in injection technique proficiency or healthcare-seeking behavior for mild AEs may contribute to the observed gender imbalance in reporting