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Taking into account the considerations mentioned above on vitiligo, it is evident that besides the genetic or constitutional susceptibility, there might be also a secondary issue associated with vitiligo which is the psychological and emotional susceptibility strongly felt by individuals permanently affected by the disease
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At moderate oxidative stress this effect small
However, studies evaluating the mechanism of protein nitration by peroxynitrite have documented an essential role of transition metals, such as iron, in the reaction mechanism [74]
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