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Although it was proposed that PYY 3-36 might exert its anorexigenic effects by activating Y2 receptors on POMC neurons in the ARC, the PYY 3-36 -induced inhibition of food intake has been shown to still occur in POMC knockout mice
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[9] However, meta-analyses have called these conclusions into question, [10] highlighting methodological problems showing no difference from a placebo, and lack of support from larger scale trials
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