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If late-stage secondary patents are now economically less valuable for small molecules, IP teams should concentrate prosecution resources on broader, earlier-stage patents that can be used to capture more commercial value during the pre-negotiation window, rather than filing dense thickets of late-stage formulation and method-of-use patents that will be economically devalued by the IRA clock
A lower dose of orforglipron was also superior, pushing blood sugar down 1.7 percentage points compared to 1.2 percentage points for lower-dose Rybelsus
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