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A systematic review of the antidepressant effects of glucagon-like peptide 1 ( GLP-1 ) functional agonists: Further link between metabolism and psychopathology Special Section on Translational and Neuroscience Studies in Affective Disorders

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The thigh: slower absorption with fewer side effects The front of the thigh is the second most popular injection site, and it has advantages that make it the preferred choice for a significant subset of GLP-1 users

GLP-1RA might also be valuable in knee osteoarthritis (KOA) amelioration, which represents the typical load-bearing complication of obesity and a leading cause of disability and reduced health-related quality of life

Significant weight loss from tirzepatide may reduce levothyroxine requirements in some patients, necessitating TSH monitoring at baseline, after substantial weight loss, and every 6-12 months once stable