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Higher insulin drives weight gain, which increases insulin resistance, which raises insulin levels even more, which further disrupts your hormones
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This modification is catalyzed by an enzymatic cascade consisting sequentially of the NEDD8-activating enzyme E1, NEDD8-conjugating enzyme E2, and substrate-specific NEDD8-E3 ligase (66)
Bradford MM
doi: 10.1089/met.2015.0095 7 MarsegliaLMantiSDAngeloGNicoteraAParisiEDi RosaGet al
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