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Keratinization of the nail plate, which is produced in the keratogenic band of the matrix, occurs abruptly without stratum granulosum, in a very similar fashion to trichilemmal keratinization.9,14,16 The epithelium of the nail bed continues distally to the matrix, is thin, and presents longitudinal crests, penetrating the underlying dermis, which can only been observed in transverse cuts.7,11,14 Finally, the distal limit of the nail consists of the hyponychium, separated from the rest of the finger by the distal nail fold.11,14,16 The dermis that supports the nail apparatus has limited cellularity and lacks any cutaneous appendages

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Baseline tests before a peptide cycle Check safety and response markers before starting

Avoid doubling up on doses to prevent potential side effects