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In clinical trials, oral semaglutide at 14 mg demonstrated HbA1c and weight reductions broadly in line with injectable semaglutide at 0.5 mg
Research progress on the GIP/GLP-1 receptor coagonist tirzepatide, a rising star in type 2 diabetes
Although a prior cohort study did not show a statistically significant reduction in major cardiovascular events among patients with no previous history of cardiovascular disease [148], a meta-analysis of eight clinical trials evaluating the effect of GLP-1R agonists on cardiovascular outcomes reported a 14% reduction in major adverse cardiovascular events, with no significant heterogeneity across GLP-1R agonists or subgroups, including patients with or without previous cardiovascular disease [149]
GLP-1 receptors also exist in the chemoreceptor trigger zone, a brain region responsible for nausea signals
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