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Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J, et al

Fatigue on semaglutide usually comes from one or more of three sources: reduced caloric intake, B12 or other nutrient deficiencies, or dehydration

GLP-1 receptor agonists lower blood sugar by stimulating insulin secretion, delaying gastric emptying, enhancing satiety, and helping lose weight

Some patients may experience loss of lean mass alongside fat loss, which could theoretically contribute to feelings of weakness or achiness, particularly if protein intake is inadequate

Occasional vomiting once or twice in the first week at a new dose does not necessarily mean tirzepatide needs to be stopped