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The recommendation is to use additional contraceptive methods (or switch to non-oral contraception) during GLP-1 therapy, especially during dose changes
The efficacy is attributed to the reduction in the synthesis of purine and pyrimidines, ATP, GTP, CTP, and TTP, along with the targeting of the TCA cycle metabolites, i.e., fumarate, malate, aspartate, and citrate, as well as NADH, essential for proper mitochondrial function
If you are using a 5mg/mL formulation , its stability profile will differ from a 10mg formulation
This makes them inherently risky which is why the FDA only permits compounding in special situations, such as drug shortages
10.1080/17512433.2021.1863788 Expert Rev Clin Pharmacol
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