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doi: 10.4049/jimmunol.164.2.959 120 PiotrowskiJ.PiotrowskiE.SkrodzkaD.SlomianyA.SlomianyB

Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, caution in those with a history of pancreatitis, increased risk of gallbladder disease, potential for acute kidney injury with dehydration, and possible worsening of diabetic retinopathy with rapid glycemic improvement

The lack of plaque rupture and thrombosis and the subsequent effect on the heart or cerebral ischemia have often led to questions of the relevance of these models for validation of novel pharmaceuticals in the field of CV disease (52)

30 Notably, 18% of patients had a prior LVEF 40, and 42% had undocumented LVEF

Our findings highlight the potential of GLP1 RAs to significantly influence HFpEF progression and improve key clinical outcomes reinforcing their role as a promising therapeutic strategy