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Retatrutide (development code LY3437943) is an investigational triple receptor agonist that simultaneously activates glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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Despite the elevated heart rate, cardiovascular outcome trials have shown net cardiovascular benefits, suggesting that the modest chronotropic effect is outweighed by other protective mechanisms

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