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Monotreme GLP-1 peptides bind with lower affinity to the GLP-1 receptor than human GLP-1 We then asked how changes in pGLP-1 and eGLP-1 affect binding and activation of the GLP-1 receptor (GLP-1R)

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This compounds an even larger problem I recently heard while speaking to a senior executive at a Pharma company: the trials are running out of patients