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By the end of the 40-week trial, the estimated changes for A1C were -1.86% for those receiving 1 mg of semaglutide and -2.01%, -2.24%, and -2.30% for those receiving the respective tirzepatide doses of 5 mg, 10 mg, and 15 mg

doi: 10.1016/j.ebiom.2019.11.051 36 CamachoCCoulourisGAvagyanVMaNPapadopoulosJBealerKet al

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Innovation pipelines need discipline, but they also need room for the strange question, otherwise we end up funding only the obvious and then wondering why the future looks less surprising

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