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It is hypothesized that palmitoylation of cGAS may impact its signaling pathway in two ways: first, it may increase cGASs binding capacity to dsDNA to promote dimer formation, and second, it may palmitoylate cGAS to improve its dimerization upon DNA recognition (69)
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There is an increasing focus on the potential contributory mechanistic role of the gut microbiota in the metabolic effects of glucoregulatory and weight loss promoting drugs, including glucagon-like peptide-1 (GLP-1) receptor agonists, which have become well-established therapies in type 2 diabetes and obesity 16,17
