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If you have heart or kidney disease or are on fluid restriction, follow your healthcare professional's specific guidance

Every patient responds differently, and factors like your starting dose, dosage adjustments, lifestyle, and unique body chemistry can influence how quickly you see results

Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a stepwise approach every four weeks until reaching the target dose of 9 mg (via steps at 2 mg, 4 mg, and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg, and 9 mg)

2025 Apr 2;10(6):1980-1992

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