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The topical application is particularly relevant for localized infections, such as skin wounds or mucosal infections, where direct delivery to the affected area can enhance efficacy and minimize systemic side effects

10.1097/ftd.0b013e318198d092 Summary Keywords tacrolimus, pharmacodynamic, pharmacokinetics, circadian rhythm, kidney transplantation, immunosuppression Citation Fontova P, Colom H, Rigo-Bonnin R, van Merendonk LN, Vidal-Alabr A, Montero N, Melilli E, Meneghini M, Manonelles A, Cruzado JM, Torras J, Griny JM, Bestard O and Lloberas N (2021) Influence of the Circadian Timing System on Tacrolimus Pharmacokinetics and Pharmacodynamics After Kidney Transplantation

doi:10.1016/j.jep.2009.10.004 Giacosa A, Guido D, Grassi M, et al