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Provincial health coverage: why no public plan covers Wegovy for weight loss No Canadian provincial or territorial health plan covers Wegovy for obesity treatment as of April 2026

Mechanism of Action Comparison# Retatrutide# Retatrutide (LY3437943) is a 39-amino acid peptide that simultaneously activates three metabolically important receptors: GLP-1 receptor : Enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes central satiety signaling GIP receptor : Potentiates insulin secretion, may improve beta-cell function, and contributes to adipose tissue metabolism Glucagon receptor : Increases hepatic glucose output acutely but chronically promotes hepatic fat oxidation, thermogenesis, and energy expenditure The glucagon receptor component distinguishes retatrutide from all other approved or late-stage metabolic peptides

Common injection sites include the upper arm, thigh, or buttocks

Researchers use it to investigate multi-receptor signaling pathways, metabolic regulation, and endocrine receptor kinetics

Your doctor can test your L carnitine levels to determine whether dietary sources are sufficient for your needs