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The addition of GIP receptor activation in Retatrutide appears to improve tolerability rather than worsen it, which is consistent with what was observed in the shift from Semaglutide to Tirzepatide

Like other GLP-1s, liraglutide is not recommended during pregnancy or breastfeeding.13 Tirzepatide (Mounjaro, Zepbound) Tirzepatide is a dual agonist that targets both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, making it distinct from other single-pathway medications