Nobody yet knows whether these effects are temporary, dose-related or limited to a subset of users
Trial data consistently show the combination arms exceeding cagrilintide-alone arms 15.6% vs 8.1% at 32 weeks in the Phase 2 diabetes trial (Frias et al., 2023), and a 22.7% combination figure at 68 weeks in REDEFINE 1 (Aronne et al., 2025)
Ongoing Clinical Support Patients can use the Direct Meds patient portal to manage refills, communicate with providers, and receive dosing guidance throughout treatment
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These can include transient nausea, facial flushing, and darkening of pre-existing moles