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Increased ROS production triggers autophagy to mediate clearing of ROS and oxidative damage (Chen et al
As we grow older, our cells produce less glutathione, which means that the antioxidant mechanism is lagging
Furthermore, human Grx1 reacts twenty times faster with GSH than with L-cysteinylglycine or L-cysteine, revealing that the preference for GSH also depends on its -glutamyl moiety 19
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