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Because the meta-analysis included both European and East Asian samples, but the validation set included primarily European samples, we separately constructed the GRS using either the European only or European and East Asian subsets of 1000 Genomes Phase 3 for clumping in PLINK

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When used, monitoring of maternal vital signs and general condition can provide reassurance that no adverse reactions (like excessive hypotension from niacinamide) are occurring

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The 5 initial loading doses are usually all that is needed for long lasting protection