When the production of ROS and RNS exceeds the antioxidant defenses, oxidative stress occurs, leading to damage to cellular components including lipids, proteins and deoxyribonucleic acid (DNA)
GLP-1RAs not only have glucose-lowering but also greater weight-loss effects as discussed in detail in a previous literature [26], the results of SELECT also suggest the weight-loss effect as an important factor explaining the cardiovascular protective effects of GLP-1RAs regardless of diabetes
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The depletion of glutathione also plays a critical role in the exacerbation of mast cell activation syndrome (MCAS) and dysautonomia, including postural orthostatic tachycardia syndrome (POTS)