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Excretion Pathways Limited data on combined excretion indicates[21]: Primarily renal elimination of peptide fragments from all components Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways (GHK-Cu component) No evidence of accumulation in chronic dosing studies of individual components BPC-157 detectable in urine for up to 4 days

However, endplate defects, e.g., Schmorls nodes, were noted more frequently

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BPC-157 complements these mechanisms through its activation of VEGFR2 and eNOS pathways that promote angiogenesis and improve endothelial function, with the peptide's nitric oxide generation supporting vasodilation and reducing thrombotic risk while its growth factor sensitization enhances vascular responses to ischemic conditions

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