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First is anti-inflammatory action and barrier maintenance: SCFAs effectively alleviate intestinal inflammatory responses and inhibit epithelial cell apoptosis, thereby preserving the structural integrity of the gut barrier
A 2022 clinical trial of people taking semaglutide found that 99% of gastrointestinal side effects were non-serious though it's worth noting the study was funded by Novo Nordisk, the maker of Ozempic and Wegovy
Analyzing existing data on GLP-1 use from insurance claims, electronic health records, and large health databases offers a more efficient approach
Elevated cortisol promotes fat storage, increases insulin resistance, and stimulates appetite through pathways that partially bypass GLP-1 signaling
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