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doi: 10.1016/j.phymed.2025.156901 158 PeiFDuanJTanLGuCMiaoJLiuSet al
Specifically, in the leaky gut state, gut microbiota dysbiosis occurs, the expression of intestinal epithelial junction proteins (e.g., tight junction proteins) decreases, and intestinal permeability increases, forming a leaky gut (165)
However, community sources and pharmaceutical handling references consistently cite refrigeration at 2-8C as the documented best practice for punctured vials, for three reasons: Reduced microbial growth rate
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