Dorr RT, Lines R, Levine N, et al
Current studies suggest that hyperglycemia is associated with a variety of poor clinical outcomes, and critically ill patients with hyperglycemia have a higher mortality rate than patients with normal blood glucose (Waeschle et al., 2008
Therefore, melanotan 2 is considered a non-selective agonist of melanocortin receptors 1, 3, 4, and 5
"Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes (SUSTAIN 5)"
The paper was in German, but it seems the researchers ramped up the stationary bike by 50 watts every two minutes until the subjects reached exhaustion