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GLP-1 plays a key role in regulating blood sugar levels by stimulating insulin release, reducing appetite, and slowing gastric emptying

Based on this and other reports, it is recommended that patients who overdose on semaglutide receive supportive care, including medications to prevent nausea and vomiting, correction of fluid and electrolyte imbalances, and close monitoring of blood sugar levels

However, these latter effects are currently only observed in animal studies

Considering this evidence, we hypothesised that activation of the GLP-1 pathway in the OB activates GABAergic neurons in the LH, which inhibit PVN neurons, reducing their stimulation of preganglionic sympathetic neurons

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