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Its typically defined by therapy gaps of 60 days or more, or when the Proportion of Days Covered (PDC) falls below 80%

You cannot simply swap the pens

What it changes is the composition of the weight you lose and the function you have at the end of it

Insulin is essential for moving glucose from the bloodstream into cells for energy, thereby lowering blood sugar

Efficacy estimand This estimand is used to assess the average treatment effect of bimagrumab, semaglutide or bimagrumab plus semaglutide for all randomized participants at weeks 48 and 72 had they received at least one dose of study treatment, adhered to protocol-defined treatment and did not discontinue treatment prematurely