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The data were, however, not compatible with a protective intention-to-treat effect. They concluded: Randomized trials using MALO as an outcome might be unfeasible, motivating further large observational studies using appropriate methodology to further delineate the effect of GLP1 agonists on the risk of MALO, complementing future phase 3 trials of GLP1 agonists.

Prioritize fluids above all else

1,2 But these are different trials in different patient groups over different time periods

The healthcare provider or your doctor may also consider reassessing the dosage or exploring alternative medications or therapies

Phase 3: Ongoing, comparing retatrutide with placebo for long-term safety and effectiveness in large groups