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The stakes here are unusually high

Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

While surgery addresses excess skin, maintaining your new body contour depends on preventing significant weight fluctuations that could compromise surgical outcomes

They may not be the right choice for people trying to conceive immediately, because weight changes and medication adjustments require careful timing

The intranasal formulations are not approved to treat acute B12 deficiency