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observed a significant increase in pro-inflammatory cytokines alongside a decrease in serotonin levels in diabetic rats, suggesting that IDO activation may contribute to depressive-like behaviors

Activation of GABA A receptors in the medial prefrontal cortex produces an anxiolytic-like response

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A cost-effectiveness analysis

Further evidence from antibiotic intervention experiments (Yarandi et al., 2020) shows that ampicillin treatment, which reduces Gram-positive bacteria and enriches Gram-negative bacteria, significantly decreases colonic nNOS enzymatic activity and nitrergic neuron count in mice, impairing colonic motility