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How peptide immunotherapy achieves tolerance The mechanisms include induction of specific T-cell anergy (functional inactivation of allergen-reactive T-cells), differentiation of naive T-cells into regulatory T-cells, immune deviation (shifting the Th2/Th1 ratio toward Th1), and allergen-specific Th2 cell deletion
Currently, it is estimated that vitiligo affects 0.52% of the global population, being the most prevalent skin disease (Krger and Schallreuter, 2012), and despite not causing any physical pain, vitiligo can generate several psychosocial disorders reducing drastically patients quality of life (Krger and Schallreuter, 2013)
Those numbers tell us what is being discussed in the research community
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