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R., Nicholls, M

Notably, chronic propionate accumulation downregulates cGMP-PKG, reducing contractility and promoting diastolic dysfunction with remodeling risk, particularly in female subjects (Park et al., 2023)

L-Propionylcarnitine (chloride) stimulates energy production in ischemic muscles by increasing citric acid cycle flux and by stimulating pyruvate dehydrogenase activity

However, most carnitines, being quaternary ammonium cation complexes, exist in ionized states under RP-LC conditions, leading to weak chromatographic retention