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Both tamoxifen and raloxifene were shown to promote anti-inflammatory effects in macrophages, stimulate fibroblast proliferation, and inhibit myofibroblast differentiation in vitro (Stevenson et al., 2009

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150 Certain natural compounds also modulate autophagy via SIRT1, improving lipid metabolism and reducing pyroptosis induced by lipid toxicity, thereby slowing MASLD progression