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319,321 Collectively, the ability of HSP70 and HSP90 to engage multiple aggregation-prone client proteins across distinct NDDs underscores their central role in neuronal proteostasis and highlights their broad therapeutic potential
The remaining work to be done is scale, not foundation.
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Two independent controlled studies using the same dose concluded the effect was of little clinical significance and not likely to be of major therapeutic benefit. Because the negative studies matched the positive studies dose, the failure cannot be explained by underdosing
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