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NRF2 is a member of the cap n collar (CNC) subfamily of the basic region leucine zipper (bZIP) transcription factors, involved in multiple cellular processes [130,131,132,133,134,135]
A.SavonenK.HassinenM.KiviniemiV.et al (2010)
It layers well with basically everything: niacinamide, hyaluronic acid, peptides, and vitamin C, and also pairs nicely with stronger actives like retinoids and exfoliating acids where it can help take the edge off irritation
The peptide also increases insulin-like growth factor 1 (IGF-1)
No 72-week obesity trial tested below 5 mg
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