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Compared to the native hormones, retatrutide shows 2.9-fold less potency at the glucagon receptor (GCCR), 2.5-fold less potency at the GLP-1 receptor, and 8.9-fold greater potency at human GIP receptor [1]
Conversely, abnormal blood glucose levels have been shown to elevate cancer risk and decrease survival rates in cancer patients [12, 50]
[9] [10] UK 'sick day rules' are relevant here: during periods of dehydration, vomiting, or acute illness which can occur in the early post-operative period ACE inhibitors, ARBs, and diuretics should generally be temporarily withheld to reduce the risk of hypotension and acute kidney injury (AKI)
Final patient advice Be curious but cautious
This mitigates sharp post-meal spikes in blood sugar, promoting more stable glucose levels throughout the day
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