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This independent PlexusDx review examines Fridays as a telehealth GLP-1 program: its compounded semaglutide and tirzepatide, 503A pharmacy fulfillment, advertised month-to-month pricing ($249/mo semaglutide and $359/mo tirzepatide as of 2026-07-20), $0 membership, and coaching supportcompared with the PlexusDx approach

For how we separate hormonal mood change from depression in the first place, see is it perimenopause or depression

Any discrepancies were resolved through discussion and, if necessary, by consulting a third investigator

Individual Case Safety Reports (ICSRs) were retrieved over the period from 1 January 2018 to 31 December 2025

10.1016/s1535-6108(03)00050-3 35 FanF.LiuP.BaoR.ChenJ.ZhouM.MoZ.et al (2021)