4.5.3 (Wallace et al., Figure 2 The results showed that PQS binds to the AhR protein through hydrophobic forces, and they appear to interact at residues Gln 277, Tyr 221, Pro 200, Ile 281, Ser 220, Phe 228, Phe 201, Ala 224, Lys 225, and Tyr 264 (Figure 2C)
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Studies of the biology of crystal handling by the kidney have shown that the formation of different crystals and other microparticles and the associated mechanisms of renal damage share molecular mechanisms, such as stimulation of the NLRP3 inflammasome or direct cytotoxicity through activation of the necroptosis signalling pathway