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Methods A protocol was developed for this systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines

1 memo to plan members, IBX officials stated that coverage for these high-cost drugs could drive up premiums for everyone, not just people taking the medications

Most gastrointestinal symptoms improve significantly within 4-8 weeks of starting treatment

These water molecules are absent from the structure of the Meisenheimer complex bound to GST, implicating that deprotonation of the cysteine occurs during formation of the ternary complex which involves expulsion of the inner bound water molecule