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The antidepressant response to LAC occurs after 3 days of administration and lasts for at least 14 days, whereas the action of standard antidepressant drugs (fluoxetine and clomipramine) requires 14 days of consecutive administration and disappears after drug withdrawal in the same rodent models [30, 34]

[15] [16] This reduces the risk of hypoglycemia compared to some other diabetes medications

This hormonal cascade alters normal digestive rhythm

The blood pressure-lowering effect appears to be driven primarily by weight loss (patients in the STEP trials lost 10-15% of body weight), though improvements in insulin sensitivity and vascular function may also contribute

And it can gradually increase the longer you stay on it