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Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor During fasting, K cells (found in the duodenum and jejunum) constitutively secrete the 42 amino acid protein GIP, which exhibits a marked increase in secretion after meals [11,12,13]
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Subsequently, a dual agonist targeting the GIP receptor, another incretin hormone, and the GLP-1 receptor was developed
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