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As a result, GLP-1(936) reduces the number of granules available for exocytosis in -cells, thereby decreasing the release of glucagon.241 This mechanism decreases intracellular Ca2+ concentration, thereby inhibiting glucagon secretion.241 Additionally, GLP-1(936) can effectively inhibit glucagon secretion induced by -adrenergic stimulation, amino acids, and membrane depolarization, indicating its inhibitory effect under various stimulatory conditions.241 In -cells of patients with T2DM, the ability of GLP-1(936) to inhibit glucagon secretion is lost

Eat slowly and chew food thoroughly

The physical transformation at six months is dramatic