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Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]
Liepinsh E et al
Phase 3 trials evaluating oral semaglutide in early-stage symptomatic Alzheimers disease did not meet their primary endpoints, tempering the earlier hypothesis that GLP-1s might offer direct neuroprotective benefits
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