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washout Timeline 1: Immediate switch (most common) Day 0: Last Wegovy injection Day 7: First Zepbound injection (2.5 mg or higher per provider instruction) Day 14: Second Zepbound injection Weeks 5, 9, 13, etc.: Dose increases per titration schedule This approach maintains continuous GLP-1 receptor agonism

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Urgent medical attention is needed for red flags such as unexplained weight loss, fever, focal neurological deficits, or inflammatory joint swelling