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Macrophage de novo NAD(+) synthesis specifies immune function in aging and inflammation
According to our current knowledge the most likely scenario is that AITC treatment causes ROS production 19,20 and induces the expression of several GSTs 17,40,41 as part of the plants detoxification system to conjugate AITC to glutathione leading to its intracellular depletion
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For necroptosis targeting, a phase I trial evaluating a SMAC mimetic (a necroptosis activator) combined with anti-PD-L1 antibody included 15 melanoma patients as part of a broader advanced solid tumor cohort (173)
doi: 10.1002/eji.201343316 168 HashimotoAHayashiIMurakamiYSatoYKitasatoHMatsushitaRet al
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