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Therefore, this in silico mutational analysis reinforces the key role of the transient residue Gly 376 for maintaining the GTP-induced inhibition dynamics
Cell 175 , 17801795 (2018)
Diagnostic test criteria for HLA genotyping to prevent drug hypersensitivity reactions: a systematic review of actionable HLA recommendations in CPIC and DPWG guidelines
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[21] Individuals of 677TT are predisposed to mild hyperhomocysteinemia (high blood homocysteine levels), because they have less active MTHFR available to produce 5-methyltetrahydrofolate (which is used to decrease homocysteine)
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