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Importantly this was based on two preclinical efficacy studies in the SOD1 G93A mouse which did not account for the now well described pitfalls in experimental design 10 , which have led to new guidelines for preclinical research
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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD + depletion
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And since obesity is chronic, weight regains are shown to occur when stopping the medication
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